tailieunhanh - Báo cáo y học: "Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration. | Available online http content 1 2 4 R88 Research Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration Tomas Regueira1 Bertram Banziger2 Siamak Djafarzadeh1 Sebastian Brandt2 Jose Gorrasi1 Jukka Takala1 Philipp M Lepper1 and Stephan M Jakob1 Department of Intensive Care Medicine Bern University Hospital Inselspital and University of Bern Freiburgstrasse CH-3010 Bern Switzerland department of Anesthesiology and Pain Therapy Bern University Hospital Inselspital and University of Bern Freiburgstrasse CH-3010 Bern Switzerland Corresponding author Stephan M Jakob stephanjakob@ Received 22 Apr 2008 Revisions requested 15 May 2008 Revisions received 30 May 2008 Accepted 14 Jul 2008 Published 14 Jul 2008 Critical Care 2008 12 R88 doi cc6956 This article is online at http content 12 4 R88 2008 Regueira et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Low blood pressure inadequate tissue oxygen delivery and mitochondrial dysfunction have all been implicated in the development of sepsis-induced organ failure. This study evaluated the effect on liver mitochondrial function of using norepinephrine to increase blood pressure in experimental sepsis. Methods Thirteen anaesthetized pigs received endotoxin Escherichia coli lipopolysaccharide B0111 B4 pg kg per hour and were subsequently randomly assigned to norepinephrine treatment or placebo for 10 hours. Norepinephrine dose was adjusted at 2-hour intervals to achieve 15 mmHg increases in mean arterial blood pressure up to 95 mmHg. Systemic thermodilution and hepatosplanchnic ultrasound Doppler blood flow were measured at each step. At .