tailieunhanh - Báo cáo y học: " Adherence to antidepressant therapy for major depressive patients in a psychiatric hospital in Thailand, "

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Adherence to antidepressant therapy for major depressive patients in a psychiatric hospital in Thailand, | Prukkanone et al. BMC Psychiatry 2010 10 64 http 1471-244X 10 64 BMC Psychiatry RESEARCH ARTICLE Open Access Adherence to antidepressant therapy for major depressive patients in a psychiatric hospital in Thailand 1 1 1 2 1 Benjamas Prukkanone Theo Vos Philip Burgess Nathorn Chaiyakunapruk Melanie Bertram Abstract Background Poor adherence to antidepressant therapy is an important barrier to the effective management of major depressive disorder. This study aims to quantify the adherence rate to antidepressant treatment and to determine the pattern of prescriptions of depressed patients in a psychiatric institute in Thailand. Methods This retrospective study used electronic pharmacy data of outpatients aged 15 or older with a new diagnosis of major depression who received at least one prescription of antidepressants between August 2005 and September 2008. The medication possession ratio MPR was used to measure adherence over a 6 month period. Results 1 058 were eligible for study inclusion. The overall adherence MPR 80 in those attending this facility at least twice was 41 but if we assume that all patients who attended only once were non-adherent adherence may be as low as 23 . Fluoxetine was the most commonly prescribed drug followed by TCAs. A large proportion of cases received more than one drug during one visit or was switched from one drug to another 39 . Conclusions Adherence to antidepressant therapy for treatment of major depression in Thailand is rather low compared to results of adherence from elsewhere. Background Depressive disorders are associated with significant health and social burden. In the Thai burden of disease study in 2004 it ranked as one of the top ten causes of Disability Adjusted Life Years DALYs 1 . Major depressive disorder is recognized as a chronic episodic disorder 2 . National treatment guidelines for major depression recommend at least six months of continuation therapy to prevent relapse and recurrence 3 . .