tailieunhanh - Báo cáo y học: "Hyperglycemia may alter cytokine production and phagocytosis by means other than hyperosmotic stress"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Hyperglycemia may alter cytokine production and phagocytosis by means other than hyperosmotic stress. | Available online http content 12 5 182 Commentary Hyperglycemia may alter cytokine production and phagocytosis by means other than hyperosmotic stress Charles E Wade US Army Institute for Surgical Research 3400 Rawley E. Chambers Avenue Fort Sam Houston TX 78234 USA Corresponding author Charles E Wade Published 9 October 2008 This article is online at http content 12 5 182 2008 BioMed Central Ltd Critical Care 2008 12 182 doi cc7012 See related research by Otto et al. http content 12 4 R107 Abstract In the previous issue of Critical Care Otto and colleagues used in vitro studies to explore the theory that immunomodulation by correction of hyperglycemia may be a contributing factor to the reported efficacy of intensive insulin therapy IIT in critically ill patients. They suggested that hyperglycemia via hyperosmolarity at supra-physiological levels potentiates the production of cytokines by peripheral blood mononuclear cells in response to lipopolysaccharide LPS stimulation and that it also reduces the responses of phagocytosis and oxidative burst in human granulocytes. The efficacy of IIT they concluded may be partially due to the correction of hyperosmolality. Other studies however have suggested that immunological responses to LPS in the presence of hyperglycemia are mediated by a mechanism other than hyperosmolality. In the previous issue of Critical Care Otto and colleagues 1 used in vitro studies to explore the theory that immunological activation induced by hyperglycemia is the result of hyperosmololaity. There is in fact a growing body of literature on osmotic regulation of cell function with possible implications on clinical outcomes 2 . At the forefront of this research is the use of hypertonic solutions to attenuate inflammation and immunosuppression following traumatic injury or sepsis 3-5 . It is widely known that administration of hypertonic solutions promotes a more balanced .