tailieunhanh - Báo cáo y học: "High mobility group box-1 protein - one step closer to the clinic"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: High mobility group box-1 protein - one step closer to the clinic? | Available online http content 12 4 168 Commentary High mobility group box-1 protein - one step closer to the clinic Tom Eirik Mollnes 1 2 Institute of Immunology University of Oslo Rikshospitalet University Hospital Sognsvannsv. 20 NO-0027 Oslo Norway 2University of Tromso Department of Laboratory Medicine Nordland Hospital Prinsensgt. 164 NO-8092 Bode Norway Corresponding author Tom Eirik Mollnes Published 17 July 2008 This article is online at http content 12 4 168 2008 BioMed Central Ltd Critical Care 2008 12 168 doi cc6944 See related research by Kornblit et al. http content 12 3 R83 Abstract High mobility group box HMGB 1 originally described as a nuclear protein that binds to and modifies DNA is now regarded as a central mediator of inflammation by acting as a cytokine. HMGB1 is postulated to be particularly important as a late acting mediator of lethal septicaemia in mice. Furthermore it has been suggested that HMGB1 plays a role in clinical conditions such as autoimmunity acute ischaemia-reperfusion injury cardiovascular disease and cancer. HMGB1 has emerged as a candidate for therapeutic intervention in various disease conditions. However further basic and clinical studies are warranted to confirm the roles played by HMGB1 in clinical medicine. In the previous issue of Critical Care Kornblit and coworkers 1 presented novel data on a possible relation between polymorphisms in the HMGB1 gene which encodes the high mobility group box HMGB 1 protein and clinical outcome in patients with systemic inflammatory response syndrome. Specifically they identified significant associations between a promoter variant -1377delA and overall late survival and between an exon 4 variant 982C T and early mortality due to infection. The latter was also associated with several clinical parameters related to disease severity. These data are of particular interest in the light of recent research suggesting a .

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