tailieunhanh - Báo cáo y học: "Cerebral microdialysis for detection of bacterial meningitis in aneurysmal subarachnoid hemorrhage patients: a cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Cerebral microdialysis for detection of bacterial meningitis in aneurysmal subarachnoid hemorrhage patients: a cohort study. | Available online http content 13 1 R2 Research Cerebral microdialysis for detection of bacterial meningitis in aneurysmal subarachnoid hemorrhage patients a cohort study Florian Schlenk1 Katja Frieler2 Alexandra Nagel1 Peter Vajkoczy1 and Asita S Sarrafzadeh1 Department of Neurosurgery Charité - Universitatsmedizin Berlin Campus Virchow Klinikum Augustenburger Platz 1 13353 Berlin Germany institute of Biometry and Clinical Epidemiology Charité - Universitatsmedizin Berlin Charitéplatz 1 1 0098 Berlin Germany Corresponding author Asita S Sarrafzadeh Received 24 Aug 2008 Revisions requested 11 Oct 2008 Revisions received 10 Nov 2008 Accepted 20 Jan 2009 Published 20 Jan 2009 Critical Care 2009 13 R2 doi cc7689 This article is online at http content 13 1 R2 2009 Schlenk et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Bacterial meningitis BM is a severe complication in patients with aneurysmal subarachnoid haemorrhage SAH . Clinical signs of meningitis are often masked by SAH-related symptoms and routine cerebrospinal fluid CSF analysis fails to indicate BM. Microdialysis MD is a technique for monitoring cerebral metabolism in patients with SAH. A cohort study was performed to investigate the value of MD for the diagnosis of BM. Methods Retrospectively 167 patients with SAH in an ongoing investigation on cerebral metabolism monitored by MD were analysed for the presence of BM and related MD changes. Diagnosis of BM was based on microbiological CSF culture or clinical symptoms responding to antibiotic treatment combined with an increased CSF cell count and or fever. Levels of MD parameters before and after diagnosis of BM were .