tailieunhanh - Báo cáo y học: " Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial. | Available online http content 1 2 4 R112 Research Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury a randomized controlled trial Jon Perez-Barcena1 2 Juan A Llompart-Pou1 Javier Homar1 Josep M Abadal1 Joan M Raurich1 Guillem Frontera3 Marta Brell4 Javier Ibanez4 and Jordi Ibanez1 Open Access Intensive Care Medicine Department Son Dureta University Hospital Andrea Doria 55 Palma de Mallorca 07014 Spain 2Surgery Department Universitat Autònoma de Barcelona UAB Bellaterra 08193 Spain investigation Unit Son Dureta University Hospital Andrea Doria 55 Palma de Mallorca 07014 Spain 4Neurosurgery Department Son Dureta University Hospital Andrea Doria 55 Palma de Mallorca 07014 Spain Corresponding author Jon Pérez-Bárcena jperez@ Received 1 Jul 2008 Revisions requested 14 Jul 2008 Revisions received 20 Aug 2008 Accepted 29 Aug 2008 Published 29 Aug 2008 Critical Care 2008 12 R112 doi cc6999 This article is online at http content 12 4 R112 2008 Pérez-Bárcena et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal. Until now no controlled studies have been conducted to compare their effectiveness even though the Brain Trauma Foundation Guidelines recommend that such studies be undertaken. The objectives of the present study were to assess the effectiveness of pentobarbital and thiopental in terms of controlling refractory intracranial hypertension in patients with severe traumatic brain injury and to evaluate the adverse effects of treatment. Methods This was a prospective .