tailieunhanh - Báo cáo y học: "a cost utility analysis of a pilot randomised controlled trial"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Controlling hypertension immediately post stroke: a cost utility analysis of a pilot randomised controlled trial. | Wilson et al. Cost Effectiveness and Resource Allocation 2010 8 3 http content 8 1 3 COST EFFECTIVENESS AND RESOURCE ALLOCATION RESEARCH Open Access Controlling hypertension immediately post stroke a cost utility analysis of a pilot randomised controlled trial A 3 rd CĨ- A in 1 m A l-circl2 Pr it ji-icr ii-i3 A nit A lictri3 O .irAA I I Cl d r4 aaHi a p Pcittdr1 Edward cl Wilson Gary A Ford om nuuiibun Amu Mistii Carol Jagger Joiin F rotter Abstract Background Elevated blood pressure BP levels are common following acute stroke. However there is considerable uncertainty if and when antihypertensive therapy should be initiated. Method Economic evaluation alongside a double-blind randomised placebo-controlled trial National Research Register Trial Number N0484128008 of 112 hypertensive patients receiving an antihypertensive regimen labetalol or lisinopril within 36 hours post stroke versus 59 receiving placebo. Outcomes were incremental cost per incremental QALY survivor and patient free from death or severe disability modified Rankin scale score 4 at three months and 14 days post stroke. Results Actively treated patients on average had superior outcomes and lower costs than controls at three months. From the perspective of the acute hospital setting there was a probability that the incremental cost per QALY gained at three months is below 30 000 although the probability may be overstated due to data limitations. Conclusion Antihypertensive therapy when indicated immediately post stroke may be cost-effective compared with placebo from the acute hospital perspective. Further research is required to confirm both efficacy and costeffectiveness and establish whether benefits are maintained over a longer time horizon. Background Approximately 52 000 patients experience first stroke 1 and 135 000 experience first or recurrent stroke in England and Wales each year 2 . It is the third biggest cause of death and the most important single

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