tailieunhanh - Báo cáo y học: "Filter survival time and requirement of blood products in patients with severe sepsis receiving drotrecogin alfa (activated) and requiring renal replacement therapy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Filter survival time and requirement of blood products in patients with severe sepsis receiving drotrecogin alfa (activated) and requiring renal replacement therapy. | Available online http content 1 2 6 R163 Open Access Research Filter survival time and requirement of blood products in patients with severe sepsis receiving drotrecogin alfa activated and requiring renal replacement therapy Luigi Camporota Eleonora Corno Eleonora Menaldo John Smith Katie Lei Richard Beale and Duncan Wyncoll Adult Intensive Care Unit Guy s and St Thomas NHS Foundation Trust St Thomas Hospital 1st Floor East Wing Lambeth Palace Road. London SE1 7EH UK Corresponding author Duncan Wyncoll Received 1 0 Sep 2008 Revisions requested 14 Oct 2008 Revisions received 10 Nov 2008 Accepted 18 Dec 2008 Published 18 Dec 2008 Critical Care 2008 12 R163 doi cc7163 This article is online at http content 12 6 R1 63 2008 Camporota et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Drotrecogin alfa activated DrotAA is licensed in the United States and the European Union for the treatment of severe sepsis with multiple organ failure. Patients with severe sepsis on renal replacement therapy RRT who typically receive additional anticoagulation to prevent circuit clotting may be at higher risk of bleeding when DrotAA is administered in addition to standard anticoagulation. However the effects of DrotAA on filter duration in the absence of additional anticoagulation have not been established. The aim of this study was to analyse the filter survival time FST and to quantify the requirement of packed red cells PRC and blood products during DrotAA infusion. Methods This was a single-centre retrospective observational study conducted in an adult intensive care unit ICU . Thirty-five patients with severe sepsis who had received both RRT and DrotAA were