tailieunhanh - Báo cáo y học: "Bench-to-bedside review: Adenosine receptors – promising targets in acute lung injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Adenosine receptors – promising targets in acute lung injury? | Available online http content 12 5 226 Review Bench-to-bedside review Adenosine receptors - promising targets in acute lung injury Carsten P Schepp1 2 and Jorg Reutershan1 Department of Anesthesiology and Intensive Care Medicine University Hospital Tubingen Hoppe-Seyler-Strasse D-72076 Tubingen Germany 2Current address Department of Anesthesiology and Intensive Care Medicine University Hospital Regensburg Franz-Josef-StrauB-Allee 92042 Regensburg Germany Corresponding author Jorg Reutershan Published 11 September 2008 This article is online at http content 12 5 226 2008 BioMed Central Ltd Critical Care 2008 12 226 doi cc6990 Abstract Acute lung injury ALI and acute respiratory distress syndrome ARDS are life-threatening disorders that have substantial adverse effects on outcomes in critically ill patients. ALI ARDS develops in response to pulmonary or extrapulmonary injury and is characterized by increased leakage from the pulmonary microvasculature and excessive infiltration of polymorphonuclear cells into the lung. Currently no therapeutic strategies are available to control these fundamental pathophysiological processes in human ALI ARDS. In a variety of animal models and experimental settings the purine nucleoside adenosine has been demonstrated to regulate both endothelial barrier integrity and polymorphonuclear cell trafficking in the lung. Adenosine exerts its effects through four G-protein-coupled receptors A1 A2A A2B and A3 that are expressed on leukocytes and nonhematopoietic cells including endothelial and epithelial cells. Each type of adenosine receptor AR is characterized by a unique pharmacological and physiological profile. The development of selective AR agonists and antagonists as well as the generation of gene-deficient mice has contributed to a growing understanding of the cellular and molecular processes that are critically involved in the development of ALI ARDS. .

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