tailieunhanh - Báo cáo y học: " Time course of plasma gelsolin concentrations during severe sepsis in critically ill surgical patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Time course of plasma gelsolin concentrations during severe sepsis in critically ill surgical patients. | Available online http content 1 2 4 R106 Open Access Research Time course of plasma gelsolin concentrations during severe sepsis in critically ill surgical patients HaiHong Wang1 BaoLi Cheng1 QiXing Chen1 2 ShuiJing Wu1 Chen Lv1 GuoHao Xie1 Yue Jin1 and XiangMing Fang1 1 Department of Anesthesiology the First Affiliated Hospital School of Medicine Zhejiang University QingChun Road Hangzhou 310003 PR China 2Key Laboratory of Multiple Organ Transplantation Ministry of Public Health the First Affiliated Hospital School of Medicine Zhejiang University QingChun Road Hangzhou 310003 PR China Contributed equally Corresponding author XiangMing Fang xiangming_fang@ Received 12 Apr 2008 Revisions requested 30 May 2008 Revisions received 7 Aug 2008 Accepted 17 Aug 2008 Published 17 Aug 2008 Critical Care 2008 12 R106 doi cc6988 This article is online at http content 12 4 R1 06 2008 Wang et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Gelsolin is an actin-binding plasma protein that is part of an actin-scavenging system. Studies suggest that plasma gelsolin may play a crucial role in the pathophysiology of sepsis. Little is known about the course of plasma gelsolin levels over time in patients with severe sepsis. The aim of the study was to investigate plasma gelsolin levels in severe septic patients and to determine whether these levels predict the severity or clinical outcome of severe sepsis. Methods Ninety-one patients who were diagnosed with severe sepsis at admission to a surgical intensive care unit were enrolled and admission plasma gelsolin levels were recorded. Plasma gelsolin levels were recorded daily in 23 of these patients. Daily plasma gelsolin levels .