tailieunhanh - Báo cáo y học: " Cost-effectiveness of ranibizumab for neovascular age-related macular degeneration"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Cost-effectiveness of ranibizumab for neovascular age-related macular degeneration. | Cost Effectiveness and Resource Allocation BioMed Central Research Cost-effectiveness of ranibizumab for neovascular age-related macular degeneration Susan F Hurley 1 2 3 Jane P Matthews1 and Robyn H Guymer4 Address Bainbridge Consultants 222 299 Queen St Melbourne VIC 3000 Australia 2School of Medicine Griffith University Australia 3School of Population Health The University of Melbourne Australia and 4Macular Research Unit Department of Ophthalmology Centre for Eye Research Australia The University of Melbourne Australia Email Susan F Hurley - susanhurley@ Jane P Matthews - janepmatthews@ Robyn H Corresponding author Open Access Published 24 June 2008 Received 14 January 2008 Cost Effectiveness and Resource Allocation 2008 6 12 doi l478-7547-6-l 2 Accepted 24 June 2008 This article is available from http content 6 l l2 2008 Hurley et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Intravitreal ranibizumab prevents vision loss and improves visual acuity in patients with neovascular age-related macular degeneration but it is expensive and efficacy beyond 2 years is uncertain. Methods We assessed the cost-effectiveness of ranibizumab compared with no ranibizumab over 10 years using randomized trial efficacy data for the first 2 years post-trial efficacy assumptions and ranibizumab acquisition costs ranging from the wholesale price 1 950 per dose to the price of bevazicumab 50 a similar molecule which may be equally efficacious. We used a computer simulation model to estimate the probability of blindness the number of

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