tailieunhanh - Báo cáo y học: "Anti-PF4/heparin antibodies associated with repeated hemofiltration-filter clotting: a retrospective study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Anti-PF4/heparin antibodies associated with repeated hemofiltration-filter clotting: a retrospective study. | Available online http content 1 2 3 R84 Research Anti-PF4 heparin antibodies associated with repeated hemofiltration-filter clotting a retrospective study Sigismond Lasocki1 Pascale Piednoir1 Nadine Ajzenberg2 Arnaud Geffroy1 Abdel Benbara1 and Philippe Montravers1 1Département d Anesthésie - Réanimation Chirurgicale APHP CHU Bichat-Claude Bernard Université Paris 7 Paris France 2Département d Hematologie APHP CHU Bichat-Claude Bernard Université Paris 7 Paris France Corresponding author Sigismond Lasocki sigismond@ Received 25 Mar 2008 Revisions requested 9 May 2008 Revisions received 19 May 2008 Accepted 25 Jun 2008 Published 25 Jun 2008 Critical Care 2008 12 R84 doi cc6937 This article is online at http content 12 3 R84 2008 Lasocki et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Heparin-induced thrombocytopenia is an immune-mediated adverse drug reaction that is associated with a procoagulant state and both arterial and venous thrombosis. After observing two cases of repeated hemofiltration-filter clotting associated with high anti-PF4 heparin antibody concentrations we systematically measured the anti-PF4 heparin antibody concentration in all cases of unexpected and repeated hemofiltration-filter clotting during continuous veno-venous hemofiltration CVVH . The aim of this study was to identify factors associated with positive anti-PF4 heparin antibody in the case of repeated hemofiltration-filter clotting. Methods We reviewed the charts of all patients who had an anti-PF4 heparin antibody assay performed for repeated hemofiltration-filter clotting between November 2004 and May 2006 in our surgical intensive care unit. We used an .