tailieunhanh - Báo cáo y học: "High-molecular-weight hyaluronan – a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: High-molecular-weight hyaluronan – a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats. | Available online http content 1 2 4 R102 Research High-molecular-weight hyaluronan - a possible new treatment for sepsis-induced lung injury a preclinical study in mechanically ventilated rats Yung-Yang Liu1 2 3 4 Cheng-Hung Lee1 2 5 Rejmon Dedaj1 2 Hang Zhao1 2 Hicham Mrabat1 2 Aviva Sheidlin6 Olga Syrkina1 2 7 Pei-Ming Huang1 2 8 Hari G Garg1 2 Charles A Hales1 2 and Deborah A Quinn1 2 Pulmonary and Critical Care Unit Department of Medicine Massachusetts General Hospital 55 Fruit Street Boston MA 02114 USA 2Harvard Medical School 25 Shattuck St Boston MA 02115 USA 3Chest Department Taipei Veterans General Hospital Sec 2 Shih-Pai Rd Taipei 11217 Taipei Taiwan 4National Yang-Ming University School of Medicine Linong Street Taipei 11 2 Taiwan 5Department of Internal Medicine National Cheng Kung University Hospital 138 Sheng-Li Road Tainan 70428 Taiwan 6Genzyme Corporation 500 Kendall Street Cambridge MA 021 42 USA 7Shriners Burn Hospital 51 Blossom Street Boston MA 02114 USA department of Traumatology and Surgery National Taiwan University Hospital No. 7 Chung-Shan S. Road Taipei 100 Taiwan Corresponding author Deborah A Quinn dquinn1 @ Received 29 Mar 2008 Revisions requested 8 May 2008 Revisions received 14 Jun 2008 Accepted 8 Aug 2008 Published 8 Aug 2008 Critical Care 2008 12 R102 doi cc6982 This article is online at http content 12 4 R1 02 2008 Liu et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Mechanical ventilation with even moderate-sized tidal volumes synergistically increases lung injury in sepsis and has been associated with proinflammatory low-molecular-weight hyaluronan production. High-molecular-weight hyaluronan