tailieunhanh - Báo cáo y học: "Are serum cytokines early predictors for the outcome of burn patients with inhalation injuries who do not survive"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Are serum cytokines early predictors for the outcome of burn patients with inhalation injuries who do not survive? | Available online http content 1 2 3 R81 Research Are serum cytokines early predictors for the outcome of burn patients with inhalation injuries who do not survive Gerd G Gauglitz1 2 Celeste C Finnerty1 2 David N Herndon1 2 Ronald P Mlcak1 and Marc G Jeschke1 2 1Shriners Hospitals for Children 815 Market Street Galveston Texas 77550 USA 2Department of Surgery University of Texas Medical Branch 301 University Boulevard Galveston Texas 77550 USA Contributed equally Corresponding author Marc G Jeschke majeschk@ Received 7 Mar 2008 Revisions requested 14 Apr 2008 Revisions received 25 Apr 2008 Accepted 18 Jun 2008 Published 18 Jun 2008 Critical Care 2008 12 R81 doi cc6932 This article is online at http content 12 3 R81 2008 Gauglitz et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Severely burned patients suffering from inhalation injury have a significantly increased risk for mortality compared with burned patients without inhalation injury. Severe burn is associated with a distinct serum cytokine profile and alterations in cytokines that contribute to morbidity and mortality. The aim of the present study was therefore to determine whether severely burned pediatric patients with concomitant inhalation injury who had a fatal outcome exhibited a different serum cytokine profile compared with burn patients with inhalation injury who survived. Early identification followed by appropriate management of these high-risk patients may lead to improved clinical outcome. Methods Thirteen severely burned children with inhalation injury who did not survive and 15 severely burned pediatric patients with inhalation injury who survived were enrolled in the study. .