tailieunhanh - Báo cáo y học: "In vitro norepinephrine significantly activates isolated platelets from healthy volunteers and critically ill patients following severe traumatic brain injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: In vitro norepinephrine significantly activates isolated platelets from healthy volunteers and critically ill patients following severe traumatic brain injury. | Available online http content 1 2 3 R80 Research In vitro norepinephrine significantly activates isolated platelets from healthy volunteers and critically ill patients following severe traumatic brain injury Christoph Tschuor1 Lars M Asmis2 Philipp M Lenzlinger3 Martina Tanner1 Luc Harter3 Marius Keel3 Reto Stocker1 and John F Stover1 Open Access 1Surgical Intensive Care Medicine University Hospital Zuerich Raemistrasse 100 CH 8091 Zuerich Switzerland institute for Clinical Hematology University Hospital Zuerich Raemistrasse 100 CH 8091 Zuerich Switzerland 3Division of Trauma Surgery Department of Surgery University Hospital Zuerich Raemistrasse 1 00 CH 8091 Zuerich Switzerland Corresponding author John F Stover Received 22 Apr 2008 Revisions requested 9 May 2008 Revisions received 3 Jun 2008 Accepted 18 Jun 2008 Published 18 Jun 2008 Critical Care 2008 12 R80 doi cc6931 This article is online at http content 12 3 R80 2008 Tschuor et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Norepinephrine regularly used to increase systemic arterial blood pressure and thus improve cerebral perfusion following severe traumatic brain injury TBI may activate platelets. This in turn could promote microthrombosis formation and induce additional brain damage. Methods The objective of this study was to investigate the influence of norepinephrine on platelets isolated from healthy volunteers and TBI patients during the first two post-traumatic weeks. A total of 18 female and 18 male healthy volunteers of different age groups were recruited while 11 critically ill TBI patients admitted consecutively to our intensive care unit were studied. Arterial and .