tailieunhanh - Báo cáo y học: " The DAOA/G30 locus and affective disorders: haplotype based association study in a polydiagnostic approach"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The DAOA/G30 locus and affective disorders: haplotype based association study in a polydiagnostic approach | Gawlik et al. BMC Psychiatry 2010 10 59 http 1471-244X 10 59 BMC Psychiatry RESEARCH ARTICLE Open Access The DAOA G30 locus and affective disorders haplotype based association study in a polydiagnostic approach 1 1 4 3 1 2 Micha Gawlik Ingeborg Wehner Meinhard Mende Sven Jung Bruno Pfuhlmann Michael Knapp Gerald Stober1 Abstract Background The DAOA G30 D-amino acid oxidase activator gene complex at chromosomal region 13q32-33 is one of the most intriguing susceptibility loci for the major psychiatric disorders although there is no consensus about the specific risk alleles or haplotypes across studies. Methods In a case-control sample of German descent affective psychosis n 248 controls n 188 we examined seven single nucleotide polymorphisms SNPs around DAOA G30 rs3916966 rs1935058 rs2391191 rs1935062 rs947267 rs3918342 and rs9558575 for genetic association in a polydiagnostic approach ICD 10 Leonhard s classification . Results No single marker showed evidence of overall association with affective disorder neither in ICD10 nor Leonhard s classification. Haplotype analysis revealed no association with recurrent unipolar depression or bipolar disorder according to ICD10 within Leonhard s classification manic-depression was associated with a 3-locus haplotype rs2391191 rs1935062 and rs3916966 P and monopolar depression with a 5-locus combination at the DAOA G30 core region P . Conclusion Our data revealed potential evidence for partially overlapping risk haplotypes at the DAOA G30 locus in Leonhard s affective psychoses but do not support a common genetic contribution of the DAOA G30 gene complex to the pathogenesis of affective disorders. Background Based on whole-genome linkage data large proportions of the distal chromosome 13q spanning 50 cM have been proposed as regions containing genes for schizophrenia bipolar disorder autism anorexia and panic disorder 1 2 . In a systematic analysis targeting on a 5 Mb segment at the distal .