tailieunhanh - Báo cáo y học: "Probiotics in the intensive care unit: why controversies and confusion abound"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Probiotics in the intensive care unit: why controversies and confusion abound. | Available online http content 12 3 160 Commentary Probiotics in the intensive care unit why controversies and confusion abound Lee E Morrow1 and Marin H Kollef2 1 Pulmonary Critical Care and Sleep Medicine Creighton University Medical Center 601 North 30th Street Suite 3820 Omaha NE 68131 USA 2Pulmonary and Critical Care Medicine Washington University Barnes-Jewish Hospital 660 South Euclid Avenue Campus Box 8052 St Louis MO 63110 USA Corresponding author Lee E Morrow lmorrow@ Published 24 June 2008 This article is online at http content 12 3 160 2008 BioMed Central Ltd Critical Care 2008 12 160 doi cc6927 See related research by Forestier et al. http content 12 3 R69 Abstract Probiotics are living microorganisms that when administered in adequate amounts confer health benefits on the host. Because probiotics are not marketed as pharmaceuticals they are commercially available without rigorous scientific documentation of their efficacy for many health-related claims. Results from existing clinical trials are both confusing and controversial. The evidence base is relatively limited includes studies with varied designs assesses multiple probiotic preparations across discrepant disease states and provides conflicting results. Recent advances in the delineation of probiotics mechanisms of action offer the opportunity to construct a more logical framework within which future trials are designed. In this era of increasing antimicrobial resistance and limited activity in the antibiotic pipeline novel nonantibiotic strategies for prevention of nosocomial infections are of particularly intense interest. The current issue of Critical Care brings us the findings of Forestier and colleagues 1 who demonstrated that oral administration of a probiotic Lactobacillus preparation delayed respiratory tract colonization with Pseudomonas aeruginosa. This delay in colonization resulted in a reduced rate of ventilator-associated .

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