tailieunhanh - Báo cáo y học: " Bench-to-bedside review: Oxygen as a drug"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Oxygen as a drug. | Available online http content 13 1 205 Review Bench-to-bedside review Oxygen as a drug Haim Bitterman Department of Internal Medicine Carmel Medical Center The Ruth and Bruce Rappaport Faculty of Medicine Technion - Israel Institute of Technology 7 Michal Street Haifa 34362 Israel Corresponding author Haim Bitterman haimb@ Published 24 February 2009 This article is online at http content 13 1 205 2009 BioMed Central Ltd Critical Care 2009 13 205 doi cc7151 Abstract Oxygen is one of the most commonly used therapeutic agents. Injudicious use of oxygen at high partial pressures hyperoxia for unproven indications its known toxic potential and the acknowledged roles of reactive oxygen species in tissue injury led to skepticism regarding its use. A large body of data indicates that hyperoxia exerts an extensive profile of physiologic and pharmacologic effects that improve tissue oxygenation exert anti-inflammatory and antibacterial effects and augment tissue repair mechanisms. These data set the rationale for the use of hyperoxia in a list of clinical conditions characterized by tissue hypoxia infection and consequential impaired tissue repair. Data on regional hemodynamic effects of hyperoxia and recent compelling evidence on its anti-inflammatory actions incited a surge of interest in the potential therapeutic effects of hyperoxia in myocardial revascularization and protection in traumatic and nontraumatic ischemic-anoxic brain insults and in prevention of surgical site infections and in alleviation of septic and nonseptic local and systemic inflammatory responses. Although the margin of safety between effective and potentially toxic doses of oxygen is relatively narrow the ability to carefully control its dose meticulous adherence to currently accepted therapeutic protocols and individually tailored treatment regimens make it a cost-effective safe drug. Oxygen is one of the most widely used therapeutic agents. It is a .

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