tailieunhanh - NEURAL TUBE DEFECTS – ROLE OF FOLATE, PREVENTION STRATEGIES AND GENETICS

Propofol is very lipid soluble, has a large volume of distribution, and can be given for prolonged periods of time without significant changes in its pharmacokinetic profile. Because propofol has no active metabolites, the termination of its clinical effect is dependent solely on redistribution to peripheral fat tissue stores. When the infusion is discontinued, the fat tissue stores redistribute. Because of its pharmacokinetics and specific effects on cerebral hemodynamic variables, preserving autoregulation and vasoreactivity to carbon dioxide, propofol approximates the ideal sedative. Intravenous bolus administration produces a dose-dependent, coupled decrease in CBF and CMRO2 similar to that described after barbiturate administration. The effects on CBF are probably secondary. | NEURAL TUBE DEFECTS - ROLE OF FOLATE PREVENTION STRATEGIES AND GENETICS Edited by Kannan Laksmi Narasimhan Neural Tube Defects - Role of Folate Prevention Strategies and Genetics Edited by Kannan Laksmi Narasimhan Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution license which allows users to download copy and build upon published articles even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. As for readers this license allows users to download copy and build upon published chapters even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Petra Nenadic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published March 2012 Printed in Croatia A free online edition of this book is available at Additional hard copies can be obtained from orders@ Neural Tube Defects - Role of Folate Prevention Strategies and Genetics Edited by Kannan