tailieunhanh - HEPATOCELLULAR CARCINOMA – CLINICAL RESEARCH

Current practice guidelines for ventilatory management advocate protective lung strategies to prevent volutrauma, barotrauma, atelectrauma and biotrauma (3-5). The principles are to use low tidal volumes (Vt) (5-6 ml/kg ideal body weight), maintenance of low mean airway pressures ≤ 30 cmH2O, judicious use of positive end-expiratory pressure (PEEP) with Δ pressure ≤ 18 cmH2O, higher respiratory rates and permissive hypercapnia. This is in direct conflict with the previous “brain-directed” ventilatory strategies that used Vt of 10 ml/kg, high FiO2 and low PEEP or zero end-expiratory pressure. There is proven mortality benefit with the use of low Vt, but permissive hypercapnia may precipitate intracranial hypertension(3,6,7). Animal studies indicate a. | HEPATOCELLULAR CARCINOMA -CLINICAL RESEARCH Edited by Wan-Yee Lau Hepatocellular Carcinoma - Clinical Research Edited by Wan-Yee Lau Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution license which allows users to download copy and build upon published articles even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. As for readers this license allows users to download copy and build upon published chapters even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Vedran Greblo Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published February 2012 Printed in Croatia A free online edition of this book is available at Additional hard copies can be obtained from orders@ Hepatocellular Carcinoma - Clinical Research Edited by Wan-Yee Lau p. cm. ISBN 978-953-51-01 12-3 INTECH open science I open minds free online editions of InTech Books .

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