tailieunhanh - Báo cáo y học: "Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial. | Available online http content 1 2 2 R61 Research Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury a randomized controlled trial Guomin Xiao1 Jing Wei2 Weiqi Yan3 Weimin Wang1 and Zhenhui Lu3 1 Department of Neurosurgery and Neurotrauma Center Affiliated Hospital College of Medicine Hangzhou Normal University Hangzhou 310015 China 2Department of Health Center Affiliated Hospital College of Medicine Hangzhou Normal University Hangzhou 310015 China 3Clinical Research Centre Second Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310009 China Contributed equally Corresponding author Weiqi Yan wyan@ Received 1 Nov 2007 Revisions requested 13 Dec 2007 Revisions received 16 Jan 2008 Published 30 Apr 2008 Critical Care 2008 12 R61 doi cc6887 This article is online at http content 12 2 R61 2008 Xiao et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Background Severe traumatic brain injury TBI has been increasing with greater incidence of injuries from traffic or sporting accidents. Although there are a number of animal models of TBI using progesterone for head injury the effects of progesterone on neurologic outcome of acute TBI patients remain unclear. The aim of the present clinical study was to assess the longer-term efficacy of progesterone on the improvement in neurologic outcome of patients with acute severe TBI. Methods A total of 159 patients who arrived within 8 hours of injury with a Glasgow Coma Score 8 were enrolled in the study. A prospective randomized placebo-controlled trial of progesterone was conducted in the Neurotrauma Center of our teaching hospital. The patients