tailieunhanh - THE ESTIMATION OF THE EFFECTIVE REPRODUCTIVE NUMBER FROM DISEASE OUTBREAK DATA

Over the years, a wide variety of methods have been developed to reduce the chances of becoming pregnant. These methods are called birth con- trol or contraception. Birth control helps a couple plan if and when to have a child. However, birth control gained even more importance in the late twentieth century for two additional reasons. The world’s human population is growing faster than at any other time in history. For example, in 1800, Earth supported a population of almost 1 billion people. By the year 2000, the human pop- ulation reached 6 billion. If the current rate of growth continues, that num- ber will double within the next. | MATHEMATICAL BIOSCIENCES AND ENGINEERING Volume 6 Number 2 April 2009 doi pp. 261-282 THE ESTIMATION OF THE EFFECTIVE REPRODUCTIVE NUMBER FROM DISEASE OUTBREAK DATA Ariel Cintrón-Arias Center for Research in Scientific Computation Center for Quantitative Sciences in Biomedicine North Carolina State University Raleigh NC 27695 USA Carlos Castillo-Chóvez Department of Mathematics and Statistics Arizona State University . Box 871804 Tempe AZ 85287-1804 USA Luis M. a. Bettencourt Theoretical Division Mathematical Modeling and Analysis T-7 Los Alamos National Laboratory Mail Stop B284 Los Alamos NM 87545 USA Alun L. Lloyd and H. T. Banks Center for Research in Scientific Computation Biomathematics Graduate Program Department of Mathematics North Carolina State University Raleigh NC 27695 USA Abstract. We consider a single outbreak susceptible-infected-recovered SIR model and corresponding estimation procedures for the effective reproductive number R t . We discuss the estimation of the underlying SIR parameters with a generalized least squares GLS estimation technique. We do this in the context of appropriate statistical models for the measurement process. We use asymptotic statistical theories to derive the mean and variance of the limiting Gaussian sampling distribution and to perform post statistical analysis of the inverse problems. We illustrate the ideas and pitfalls . large condition numbers on the corresponding Fisher information matrix with both synthetic and influenza incidence data sets. 1. Introduction. The transmissibility of an infection can be quantified by its basic reproductive number R0 defined as the mean number of secondary infections seeded by a typical infective into a completely susceptible naive host population 1 19 26 . For many simple epidemic processes this parameter determines a threshold whenever R0 1 a typical infective gives rise on average to more than one secondary infection leading to an epidemic. In .

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