tailieunhanh - Reproductive health in male systemic lupus erythematosus

In most women, the menstrual cycle continues for at least 40 years from puberty. Between the ages of 45 and 55, the levels of hormones change; the menstrual cycle becomes less regular and eventually stops. This stage, called menopause, marks the point at which a female is no longer capable of reproducing. Menopause is a normal occurrence in all women; however, the effects of menopause vary widely from one woman to another. In men, by contrast, sperm production continues throughout life, although the number of healthy sperm likely declines with age | original article Reproductive health in male systemic lupus erythematosus Clovis Artur Almeida da Silva 1 Eloísa Bonfá2 Eduardo Ferreira Borba3 Aline Presto Braga4 Pollyana Maria Ferreira Soares5 Ana Julia Pantoja de Moraes6 Osmar Saito7 Marcello Cocuzza8 ABSTRACT Objective To assess reproductive health in male systemic lupus erythematosus SLE patients and compare them with controls. Methods Twenty-five male SLE patients were evaluated for demographic data urologic evaluation including pubertal parameters sexual erectile function testicular Doppler ultrasound hormone profile semen analysis clinical features and treatment. The control group included 25 healthy men. Results The current median age was similar in SLE patients compared with controls 26 versus 27 years P . The frequencies of sexual erectile disfunction were significantly higher 20 versus 0 P and the number of spontaneous pregnancies were lower in SLE patients than in controls 20 versus 60 P . A trend to low contraceptive use was observed in SLE patients compared with controls 48 versus 76 P . Moreover the frequencies of gonadal dysfunction parameters such as testicular atrophies measured by ultrasound 36 versus 8 P elevated FSH and or LH levels 36 versus 0 P and sperm abnormalities 48 versus 0 P were statistically higher in SLE patients versus controls. SLE patients with sexual erectile disfunction had no sexual activity in the last month versus 95 of SLE patients without dysfunction P . On the other hand no differences were evidenced in SLE patients with or without sexual erectile disfunction according to demographic data disease activity cumulative damage and treatment. Conclusion This is the first study to identify sexual erectile and gonadal disfunction in male SLE patients. A multidisciplinary approach is essential in order to offer preventive measures for these patients. Keywords reproductive health sexual function sperm hormone systemic lupus .