tailieunhanh - DNA METHYLATION – FROM GENOMICS TO TECHNOLOGY

Changes in the pattern of DNA methylation are commonly seen in human tumors. Both genome wide hypomethylation (insufficient methylation) and region-specific hypermethylation (excessive methylation) have been suggested to play a role in carcinogenesis2. A common cause of the loss of tumor-suppressor miRNAs in cancer is the silencing of primary transcripts by CpG island promoter by hypermethylation3. DNA hypomethylation also contributes to cancer development via three major mechanisms, such as: an increase in genomic instability, reactivation of transposable elements and loss of imprinting | DNA METHYLATION -FROM GENOMICS TO TECHNOLOGY Edited by Tatiana Tatarinova and Owain Kerton DNA Methylation - From Genomics to Technology Edited by Tatiana Tatarinova and Owain Kerton Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution license which allows users to download copy and build upon published articles even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. As for readers this license allows users to download copy and build upon published chapters even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Iva Simcic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published March 2012 Printed in Croatia A free online edition of this book is available at Additional hard copies can be obtained from orders@ DNA Methylation - From Genomics to Technology Edited by Tatiana Tatarinova and Owain Kerton p. cm. ISBN 978-953-51-0320-2 .

• Sinh học
• Systemic Therapy
• Advanced Pancreatic Carcinoma
• Immunotherapy
• Overview
• Bacterial Immunotherapy
• Antitumoral Potential
• Hepatocellular carcinoma
• Systemic therapy for hepatocellular carcinoma
• Adjuvant regimens for HCC
• Sorafenib was first approved
• Prolong survival of the patients
• Barcelona Classification
• Summary of doctoral thesis
• Immune disorders and results of pulse methylprednisolone therapy
• Severe systemic lupus erythematosus
• Target organ damage and activity level
• Pulsed methylprednisolone therapy combined
• BMC Cancer
• Adjuvant temozolomide
• Multimodality therapy approaches
• Systemic treatment
• Radiation therapy
• BMC Pulmonary medicine
• Systemic glucocorticoid therapy
• Plasma metabolome
• Systemic glucocorticoid
• Acute exacerbation
• Chronic obstructive pulmonary disease
• Phase II trial
• Selective internal radiation therapy
• Systemic chemotherapy
• Liver predominant metastases
• Pancreatic adenocarcinoma
• Bladder cancer
• Radical cystectomy
• Perioperative chemotherapy
• Perioperative targeted therapy
• Immune therapy
• Gene therapy
• Human HCC cells
• Modified molecule
• Systemic HCC therapy
• Ewing sarcoma
• Complete remission
• Metastatic disease
• Distant metastasis
• Biliary cancer
• Younger patients
• Prospective trials
• Corticosteroids and steroid therapy
• Steroid therapy
• The manager
• Chronic subdural hematoma
• Clinical considerations
• Systemic autoimmune diseases
• Risk factors
• Intrauterine therapy
• Hormonal therapy
• Metritis in cattle
• Competitive mortality
• Non tumoral death
• Head and neck cancer
• Breast cancer
• Neoadjuvant systemic therapy
• Nodal staging
• Chest CT
• BMC Musculoskeletal Disorders
• Rheumatoid arthritis
• Systemic lupus erythematosus
• Autoimmune disorders
• Osteoporotic fractures
• BMC Anesthesiology
• Local anesthetic systemic toxicity
• Lipid rescue therapy
• Intravenous lipid emulsions
• Several international anesthesia organizations
• Carbon monoxide
• Life threatening
• Systemic hyperbaric oxygen
• CO detoxification
• Severely intoxicated patients
• Prognostic models
• Review and critical appraisal
• Advanced hepatocellular carcinoma
• Liver cancer
• Randomized controlled trial
• Systemic anticancer therapy
• Targeted therapy
• Non standard
• Survival outcomes
• Slow growing neoplasm
• Radiological response
• Pancreatic cancer
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• Second line therapy Progression free survival
• Overall survival
• Biliary tract cancer
• Combination therapy
• Prior systemic therapies
• Prospective randomized
• Neoadjuvant treatment
• Endocrine therapy
• Treatment response
• Post treatment surgical management