tailieunhanh - Book: CELL METABOLISM – CELL HOMEOSTASIS AND STRESS RESPONSE

“Epigenetics” as introduced by ConradWaddington in 1946, is defined as a set of interactions between genes and the surrounding environment, which determines the phenotype or physical traits in an organism, (Murrell et al., 2005;Waddington, 1942). Initial research focused on genomic regions such as heterochromatin and euchromatin based on dense and relatively loose DNA packing, since these were known to contain inactive and active genes respectively, (Yasuhara et al., 2005). Subsequently, key roles of DNA methylation, Histone Modifications and other assistive proteins such as Methyl Binding Proteins (MBP) during gene expression and suppression were identified, (Baylin & Ohm, 2006; Jenuwein & Allis, 2001). An emergent and persistent view that. | CELL METABOLISM - CELL HOMEOSTASIS AND STRESS RESPONSE Edited by Paula Bubulya Cell Metabolism - Cell Homeostasis and Stress Response Edited by Paula Bubulya Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2011 InTech All chapters are Open Access distributed under the Creative Commons Attribution license which allows users to download copy and build upon published articles even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. As for readers this license allows users to download copy and build upon published chapters even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Igor Babic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published January 2012 Printed in Croatia A free online edition of this book is available at Additional hard copies can be obtained from orders@ Cell Metabolism - Cell Homeostasis and Stress Response Edited by Paula Bubulya p. cm. ISBN 978-953-307-978-3 ikrrr iJ OPEN ACCESS INI Cvn PUBLISHER