tailieunhanh - Báo cáo y học: " Is antipsychotic polypharmacy associated with metabolic syndrome even after adjustment for lifestyle effects?: a cross-sectional study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Is antipsychotic polypharmacy associated with metabolic syndrome even after adjustment for lifestyle effects?: a cross-sectional study | Misawa et al. BMC Psychiatry 2011 11 118 http 1471-244X 11 118 BMC Psychiatry RESEARCH ARTICLE Open Access Is antipsychotic polypharmacy associated with metabolic syndrome even after adjustment for lifestyle effects a cross-sectional study 1 2 1 1 1 1 Fuminari Misawa Keiko Shimizu Yasuo Fujii Ryouji Miyata Fumio Koshiishi Mihoko Kobayashi I_I I l 71 I c I I 1 ri ỉ I rr I I r I 1 V I n I I Ỉ I m I im3 I_I I rz z I Fz-V 3 h ỉ I IX - r y m - 4 I I_l- ri lz IX r I m 5 Hirokazu Shida Yoshiyo Oguchi Yasuyuki Okumura Hiroto Ito Mami Kayama and Haruo Kashima Abstract Background Although the validity and safety of antipsychotic polypharmacy remains unclear it is commonplace in the treatment of schizophrenia. This study aimed to investigate the degree that antipsychotic polypharmacy contributed to metabolic syndrome in outpatients with schizophrenia after adjustment for the effects of lifestyle. Methods A cross-sectional survey was carried out between April 2007 and October 2007 at Yamanashi Prefectural KITA hospital in Japan. 334 patients consented to this cross-sectional study. We measured the components consisting metabolic syndrome and interviewed the participants about their lifestyle. We classified metabolic syndrome into four groups according to the severity of metabolic disturbance the metabolic syndrome the pre-metabolic syndrome the visceral fat obesity and the normal group. We used multinomial logistic regression models to assess the association of metabolic syndrome with antipsychotic polypharmacy adjusting for lifestyle. Results Seventy-four patients were in the metabolic syndrome group 61 patients were in the pre-metabolic syndrome group and 41 patients were in visceral fat obesity group. Antipsychotic polypharmacy was present in 167 patients. In multinomial logistic regression analyses antipsychotic polypharmacy was significantly associated with the pre-metabolic syndrome group adjusted odds ratio AOR 95 .