tailieunhanh - Báo cáo y học: " Is Ankyrin a genetic risk factor for psychiatric phenotypes?"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Is Ankyrin a genetic risk factor for psychiatric phenotypes? | Gella et al. BMC Psychiatry 2011 11 103 http 1471-244X 11 103 BMC Psychiatry RESEARCH ARTICLE Open Access Is Ankyrin a genetic risk factor for psychiatric phenotypes 111 2 2 2 Alejandro Gella Mònica Segura Núria Durany Bruno Pfuhlmann Gerald Stober and Micha Gawlik Abstract Background Genome wide association studies reported two single nucleotide polymorphisms in ANK3 rs9804190 and rs10994336 as independent genetic risk factors for bipolar disorder. Another SNP in ANK3 rs10761482 was associated with schizophrenia in a large European sample. Within the debate on common susceptibility genes for schizophrenia and bipolar disorder we tried to investigate common findings by analyzing association of ANK3 with schizophrenia bipolar disorder and unipolar depression. Methods We genotyped three single nucleotide polymorphisms SNPs in ANK3 rs9804190 rs10994336 and rs10761482 in a case-control sample of German descent including 920 patients with schizophrenia 400 with bipolar affective disorder 220 patients with unipolar depression according to ICD 10 and 480 healthy controls. Sample was further differentiated according to Leonhard s classification featuring disease entities with specific combination of bipolar and psychotic syndromes. Results We found no association of rs9804190 and rs10994336 with bipolar disorder unipolar depression or schizophrenia. In contrast to previous findings rs10761482 was associated with bipolar disorder p but not with schizophrenia or unipolar depression. We observed no association with disease entities according to Leonhard s classification. Conclusion Our results support a specific genetic contribution of ANK3 to bipolar disorder though we failed to replicate findings for schizophrenia. We cannot confirm ANK3 as a common risk factor for different diseases. Background Schizophrenia and bipolar disorder are genetically complex diseases with numerous proposed genetic risk factors encompassing different pathophysiological