tailieunhanh - Báo cáo y học: "Bench-to-bedside review: The value of cardiac biomarkers in the intensive care patient"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: The value of cardiac biomarkers in the intensive care patient. | Available online http content 12 3 215 Review Bench-to-bedside review The value of cardiac biomarkers in the intensive care patient Anthony S McLean Stephen J Huang and Mark Salter Department of Intensive Care Medicine Nepean Hospital University of Sydney Sydney NSW 2750 Australia Corresponding author Anthony S McLean mcleana@ Published 2 June 2008 This article is online at http content 12 3 215 2008 BioMed Central Ltd Critical Care 2008 12 215 doi cc6880 Abstract The use of cardiac biomarkers in the intensive care setting is gaining increasing popularity. There are several reasons for this increase there is now the facility for point-of-care biomarker measurement providing a rapid diagnosis biomarkers can be used as prognostic tools biomarkers can be used to guide therapy and compared with other methods such as echocardiography the assays are easier and much more affordable. Two important characteristics of the ideal biomarker are disease specificity and a linear relationship between the serum concentration and disease severity. These characteristics are not present however in the majority of biomarkers for cardiac dysfunction currently available. Those clinically useful cardiac biomarkers which naturally received the most attention such as troponins and B-type natriuretic peptide are not as specific as was originally thought. In the intensive care setting it is important for the user to understand the degree of specificity of these biomarkers and that the interpretation of the results should always be guided by other clinical information. The present review summarizes the available biomarkers for different cardiac conditions. Potential biomarkers under evaluation are also briefly discussed. Introduction Nearly 30 of patients admitted to a general intensive care unit ICU have underlying cardiac diseases and approximately one-half of these 30 are admitted to the ICU with cardiac problems as the primary cause 1 2 . The