tailieunhanh - Báo cáo y học: "Bench-to-bedside review: Sepsis, severe sepsis and septic shock – does the nature of the infecting organism matter"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Sepsis, severe sepsis and septic shock – does the nature of the infecting organism matter? | Available online http content 12 3 213 Review Bench-to-bedside review Sepsis severe sepsis and septic shock -does the nature of the infecting organism matter Hongmei Gao Timothy W Evans and Simon J Finney Adult Intensive Care Unit Royal Brompton Hospital Sydney Street London SW3 6NP UK Corresponding author Timothy Evans Published 6 May 2008 This article is online at http eontent 12 3 213 2008 BioMed Central Ltd Critical Care 2008 12 213 doi cc6862 Abstract International guidelines concerning the management of patients with sepsis septic shock and multiple organ failure make no reference to the nature of the infecting organism. Indeed most clinical signs of sepsis are nonspecific. In contrast in vitro data suggest that there are mechanistic differences between bacterial viral and fungal sepsis and imply that pathogenetic differences may exist between subclasses such as Gram-negative and Grampositive bacteria. These differences are reflected in different cytokine profiles and mortality rates associated with Gram-positive and Gram-negative sepsis in humans. They also suggest that putative anti-mediator therapies may act differently according to the nature of an infecting organism. Data from some clinical trials conducted in severe sepsis support this hypothesis. It is likely that potential new therapies targeting for example Toll-like receptor pathways will require knowledge of the infecting organism. The advent of new technologies that accelerate the identification of infectious agents and their antimicrobial sensitivities may allow better tailored anti-mediator therapies and administration of antibiotics with narrow spectra and known efficacy. Introduction Sepsis and its sequelae namely severe sepsis septic shock and multiple organ failure dominate the case load of noncoronary intensive care units ICUs . Despite a fall in mortality deaths attributable to sepsis have risen in developed countries as the incidence .

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.