tailieunhanh - Báo cáo y học: "Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial. | Available online http content 1 2 2 R52 Research Melatonin therapy to improve nocturnal sleep in critically ill patients encouraging results from a small randomised controlled trial Richard S Bourne1 Gary H Mills2 and Cosetta Minelli3 1Sheffield Teaching Hospitals Critical Care Department Northern General Hospital Herries Road Sheffield UK S5 7AU 2Sheffield Teaching Hospitals Critical Care Directorate Royal Hallamshire Hospital Glossop Road Sheffield UK S1 0 2JF 3Respiratory Epidemiology and Public Health Group National Heart and Lung Institute Imperial College London Emmanuel Kaye Building Manresa Road London UK SW3 6lR Corresponding author Richard S Bourne Received 8 Feb 2008 Revisions requested 13 Mar 2008 Revisions received 11 Apr 2008 Accepted 1 8 Apr 2008 Published 18 Apr 2008 Critical Care 2008 12 R52 doi cc6871 This article is online at http content 12 2 R52 2008 Bourne et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Sleep disturbances are common in critically ill patients and when sleep does occur it traverses the day-night periods. The reduction in plasma melatonin levels and loss of circadian rhythm observed in critically ill patients receiving mechanical ventilation may contribute to this irregular sleepwake pattern. We sought to evaluate the effect of exogenous melatonin on nocturnal sleep quantity in these patients and furthermore to describe the kinetics of melatonin after oral administration in this patient population thereby guiding future dosing schedules. Methods We conducted a randomised double-blind placebo-controlled trial in 24 patients who had undergone a tracheostomy to aid weaning from mechanical .

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