tailieunhanh - Báo cáo khoa học: " Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis. | Available online http content 1 2 1 R25 Research Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis Paulo S Martins1 Milena KC Brunialti1 Leandro SW Martos1 Flavia R Machado2 Murillo S Assunọao2 Sergio Blecher3 and Reinaldo Salomao1 Open Access Division of Infectious Diseases Escola Paulista de Medicina Federal University of Sao Paulo Brazil intensive Care Unit Hospital Sao Paulo Federal University of Sao Paulo Brazil intensive Care Unit Hospital Santa Marcelina Sao Paulo Brazil Contributed equally Corresponding author Reinaldo Salomao rsalomao-dipa@ Received 4 Oct 2007 Revisions requested 1 4 Nov 2007 Revisions received 21 Dec 2007 Accepted 13 Feb 2008 Published 13 Feb 2008 Critical Care 2008 12 R25 doi cc6801 This article is online at http content 12 1 R25 2008 Martins et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Infection control depends on adequate microbe recognition and cell activation yet inflammatory response may lead to organ dysfunction in sepsis. The aims of this study were to evaluate cell activation in the context of sepsis and its correlation with organ dysfunction. Methods A total of 41 patients were prospectively enrolled 14 with sepsis 12 with severe sepsis and 15 with septic shock. A total of 17 healthy volunteers were included as a control group. Patients were admitted to the Intensive Care Units and Emergency Rooms of Hospital Sao Paulo Federal University of Sao Paulo and Hospital Santa Marcelina Sao Paulo Brazil. Toll-like receptor TLR 2 TLR4 CD11b CD11c and CD66b expression on neutrophil surfaces and oxidative metabolism measured by non-fluorescent dichlorofluorescein .