tailieunhanh - Báo cáo khoa học: "Monocyte deactivation in neutropenic acute respiratory distress syndrome patients treated with granulocyte colony-stimulating factor"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Monocyte deactivation in neutropenic acute respiratory distress syndrome patients treated with granulocyte colony-stimulating factor. | Available online http content 1 2 1 R17 Research Monocyte deactivation in neutropenic acute respiratory distress syndrome patients treated with granulocyte colony-stimulating factor Djamel Mokart1 Eric Kipnis2 Pierre Guerre-Berthelot1 Norbert Vey4 Christian Capo3 Antoine Sannini1 Jean-Paul Brun1 Jean-Louis Blache1 Jean-Louis Mege3 Didier Blaise4 and Benoit P Guery2 Department of Anesthesiology and Intensive Care Unit Paoli-Calmette Institute 232 bd Sainte Marguerite 13273 Marseille Cedex 9 France 2EA2689 SGRIVI Hopital Calmette CHRU de Lille 59037 Lille Cedex laboratory of Immunology and Hematology Hôpital de la Conception Marseille France 4Department of Hematology Paoli-Calmette Institute Marseille France Corresponding author Djamel Mokart mokartd@ Received 12 Jun 2007 Revisions requested 27 Jul 2007 Revisions received 9 Jan 2008 Accepted 18 Feb 2008 Published 18 Feb 2008 Critical Care 2008 12 R17 doi cc6791 This article is online at http content 12 1 R1 7 2008 Mokart et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction In severely neutropenic septic acute respiratory distress syndrome ARDS patients macrophages and monocytes are the last potentially remaining innate immune cells. We have previously shown however a deactivation of the alveolar macrophage in neutropenic septic ARDS patients. In the present study we tried to characterize in vitro monocyte baseline cytokine production and responsiveness to lipopolysaccharide exposure. Methods Twenty-two consecutive patients with cancer were prospectively enrolled into a prospective observational study in an intensive care unit. All patients developed septic ARDS and were divided into two .