tailieunhanh - Báo cáo khoa học: "Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study. | Available online http content 11 6 R127 Open Access Research Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury morbidity and mortality after pediatric cardiac surgery a prospective uncontrolled cohort study Catherine L Dent1 Qing Ma2 Sudha Dastrala2 Michael Bennett2 Mark M Mitsnefes2 Jonathan Barasch3 and Prasad Devarajan2 1 Department of Cardiology Cincinnati Children s Hospital Medical Center University of Cincinnati School of Medicine 3333 Burnet Ave Cincinnati Ohio 45229 USA 2Department of Nephrology Hypertension Cincinnati Children s Hospital Medical Center University of Cincinnati School of Medicine 3333 Burnet Ave Cincinnati Ohio 45229 USA Department of Nephrology College of Physicians and Surgeons Columbia University 630 West 168th Street New York New York 10032 USA Corresponding author Prasad Devarajan Received 20 Sep 2007 Revisions requested 19 Oct 2007 Revisions received 26 Nov 2007 Accepted 10 Dec 2007 Published 10 Dec 2007 Critical Care 11 R127 doi cc6192 This article is online at http content 11 6 R1 27 2007 Dent . licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Acute kidney injury AKI is a frequent complication of cardiopulmonary bypass CPB . The lack of early biomarkers has impaired our ability to intervene in a timely manner. We previously showed in a small cohort of patients that plasma neutrophil gelatinase-associated lipocalin NGAL measured using a research enzyme-linked immunosorbent assay is an early predictive biomarker of AKI after CPB. In this study we tested whether a point-of-care NGAL device can predict AKI after CPB in a larger cohort. Methods First in a cross-sectional pilot study .