tailieunhanh - Báo cáo y học: "Early response predicts subsequent response to olanzapine long-acting injection in a randomized, double-blind clinical trial of treatment for schizophrenia"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Early response predicts subsequent response to olanzapine long-acting injection in a randomized, double-blind clinical trial of treatment for schizophrenia | Ascher-Svanum et al. BMC Psychiatry 2011 11 152 http 1471-244X 11 152 BMC Psychiatry RESEARCH ARTICLE Open Access Early response predicts subsequent response to olanzapine long-acting injection in a randomized double-blind clinical trial of treatment for schizophrenia 1 I- 71 2 2 3 1 2 Haya Ascher-Svanum Fangyi Zhao Holland C Detke Allen W Nyhuis Anthony H Lawson Virginia L Stauffer William Montgomery4 Michael M Witte3 and David P McDonnell5 Abstract Background In patients with schizophrenia early non-response to oral antipsychotic therapy robustly predicts subsequent non-response to continued treatment with the same medication. This study assessed whether early response predicted later response when using a long-acting injection LAI antipsychotic. Methods Data were taken from an 8-week randomized double-blind placebo-controlled study of olanzapine LAI in acutely ill patients with schizophrenia n 233 . Early response was defined as 30 improvement from baseline to Week 4 in Positive and Negative Syndrome Scale PANSS0-6 Total score. Subsequent response was defined as 40 baseline-to-endpoint improvement in PANSS0-6 Total score. Sensitivity specificity positive predictive value PPV negative predictive value NPV and predictive accuracy were calculated. Clinical and functional outcomes were compared between Early Responders and Early Non-responders. Results Early response non-response to olanzapine LAI predicted later response non-response with high sensitivity 85 specificity 72 PPV 78 NPV 80 and overall accuracy 79 . Compared to Early Non-responders Early Responders had significantly greater improvement in PANSS0-6 Total scores at all time points and greater baseline-to-endpoint improvement in PANSS subscale scores Quality of Life Scale scores and Short Form-36 Health Survey scores all p .01 . Among Early Non-responders 20 demonstrated response by Week 8. Patients who lacked early improvement at Week 4 in Negative Symptoms and Disorganized Thoughts