tailieunhanh - Báo cáo y học: " Sustained favorable long-term outcome in the treatment of schizophrenia: a 3-year prospective observational study"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Sustained favorable long-term outcome in the treatment of schizophrenia: a 3-year prospective observational study | Cuyún Carter et al. BMC Psychiatry 2011 11 143 http 1471-244X 11 143 BMC Psychiatry RESEARCH ARTICLE Open Access Sustained favorable long-term outcome in the treatment of schizophrenia a 3-year prospective observational study Gebra B Cuyún Carter Denái R Milton Haya Ascher-Svanum and Douglas E Faries Abstract Background This study of chronically ill patients with schizophrenia aimed to identify patients who achieve sustained favorable long-term outcome - when the outcome incorporates severity of symptoms level of functioning and use of acute care services - and to identify the best baseline predictors of achieving this sustained favorable long-term outcome. Methods Using data from the United States Schizophrenia Care and Assessment Program US-SCAP N 2327 a large 3-year prospective multisite observational study of individuals treated for schizophrenia in the US a hierarchical cluster analysis was performed to group patients based upon baseline symptom severity. Symptom severity was assessed using the Positive and Negative Syndrome Scale PANSS scores level of functioning and use of acute care services. Level of functioning reflected patient-reported productivity and clinician-rated occupational role functioning. Use of acute care services reflected self-reported psychiatric hospitalization and emergency service use. Change of health state was determined over the 3-year period. A patient was classified as having a sustained favorable long-term outcome if their health state values had the closest distance to the defined best baseline cluster at each point over the length of the study. Stepwise logistic regression was used to determine baseline predictors of sustained favorable long-term outcome. Results At baseline 5 distinct health state clusters were identified ranging from best to worst. Of 1635 patients with sufficient data only 157 10 experienced sustained favorable long-term outcome during the 2-years postbaseline. The baseline predictors .