tailieunhanh - Báo cáo y học: "Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers. | Ebihara et al. Cough 2011 7 3 http content 7 1 3 Cough RESEARCH Open Access Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers 1 2 1 1 2 2 Satoru Ebihara Takae Ebihara Masashi Kanezaki Peijun Gui Miyako Yamasaki Hiroyuki Arai and Masahiro Kohzuki1 Abstract Background The effect of aging on the cognitive aspect of cough has not been studied yet. The purpose of this study is to investigate the aging effect on the perception of urge-to-cough in healthy individuals. Methods Fourteen young female healthy never-smokers were recruited via public postings. Twelve elderly female healthy never-smokers were recruited from a nursing home residence. The cough reflex threshold and the urge-to-cough were evaluated by inhalation of citric acid. The cough reflex sensitivities were defined as the lowest concentration of citric acid that elicited two or more coughs C2 and five or more coughs C5 . The urge-to-cough was evaluated using a modified the Borg scale. Results There was no significant difference in the cough reflex threshold to citric acid between young and elderly subjects. The urge-to-cough scores at the concentration of C2 and C5 were significantly smaller in the elderly than young subjects. The urge-to-cough log-log slope in elderly subjects point L g was significantly gentler than those of young subjects point L g p . There were no significant differences in the urge-to-cough threshold estimated between young and elderly subjects. Conclusions The cough reflex threshold did not differ between young and elderly subjects whereas cognition of urge-to-cough was significantly decreased in elderly subjects in female never-smokers. Objective monitoring of cough might be important in the elderly people. Background It has been suggested that the increased incidence of pneumonia with aging may be a consequence of impairment of the cough reflex with senescence 1 .