tailieunhanh - Báo cáo y học: "Objective cough frequency in Idiopathic Pulmonary Fibrosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Objective cough frequency in Idiopathic Pulmonary Fibrosis. | Key et al. Cough 2010 6 4 http content 6 1 4 Cough RESEARCH Open Access Objective cough frequency in Idiopathic Pulmonary Fibrosis Angela L Key31 1 3 Kimberley Holt31 3 Andrew Hamilton32 Jaclyn A Smith32 and John E Earls 31 3 Abstract Background Cough is a common presenting symptom in patients with Idiopathic Pulmonary Fibrosis IPF . This study measured cough rates in IPF patients and investigated the association between cough and measures of health related quality of life and subjective cough assessments. In addition IPF cough rates were related to measures of physiological disease severity and compared to cough rates in health and other respiratory conditions. Methods Nineteen IPF patients mean age years five female were studied. Subjects performed full pulmonary function testing 24 hour ambulatory cough recordings completed a cough related quality of life questionnaire Leicester Cough Questionnaire and subjectively scored cough severity with a visual analogue scale. Ambulatory cough recordings were manually counted and reported as number of coughs per hour. Results The 24hr cough rates were high median range with day time rates much higher than night time median range compared to range p . Strong correlations were found between objective cough frequency and both the VAS day r p night r p and LCQ r p but not with measures of pulmonary function. Cough rates in IPF were higher than healthy subjects p and asthma patients p but similar to patients with chronic cough p . Conclusions This study confirms objectively that cough is a major very distressing and disabling symptom in IPF patients. The strong correlations between objective cough counts and cough related quality of life measures suggest that in IPF patient s perception of cough frequency is very accurate. Background Idiopathic Pulmonary Fibrosis IPF is a progressive fibrotic disease

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