tailieunhanh - Báo cáo y học: " Coordinate enhancement of transgene transcription and translation in a lentiviral vector"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:Coordinate enhancement of transgene transcription and translation in a lentiviral vector | BioMed Central Retrovirology Research Coordinate enhancement of transgene transcription and translation in a lentiviral vector Open Access Alper Yilmaz1 5 Soledad Fernandez3 4 Michael D Lairmore1 2 4 5 and Kathleen Boris-Lawrie 1 2 4 5 Address 1Center for Retrovirus Research and Department of Veterinary BioscienceS The Ohio State University ColumbuS OH 43210 USA 2Department of Molecular Virology Immunology Medical Genetics The Ohio State University Columbus OH 43210 USA 3Center for Biostatistics The Ohio State University Columbus OH 43210 USA 4Comprehensive Cancer Center The Ohio State University Columbus OH 43210 USA and 5Molecular Cellular Developmental Biology Graduate Program The Ohio State University Columbus OH 43210 USA Email AlperYilmaz - Soledad Fernandez - Michael D Lairmore - Kathleen Boris-Lawrie - Corresponding author Published 15 February 2006 Received 06 January 2006 Accepted 15 February 2006 Retrovirology 2006 3 13 doi l 742-4690-3-1 3 This article is available from http content 3 1 1 3 2006 Yilmaz et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Coordinate enhancement of transgene transcription and translation would be a potent approach to significantly improve protein output in a broad array of viral vectors and nonviral expression systems. Many vector transgenes are complementary DNA cDNA . The lack of splicing can significantly reduce the efficiency of their translation. Some retroviruses contain a 5 terminal post-transcriptional control element PCE that facilitates translation of unspliced mRNA. Here we evaluated the potential for spleen necrosis virus PCE to stimulate

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