tailieunhanh - Báo cáo y học: " Intracytoplasmic maturation of the human immunodeficiency virus type 1 reverse transcription complexes determines their capacity to integrate into chromatin"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Intracytoplasmic maturation of the human immunodeficiency virus type 1 reverse transcription complexes determines their capacity to integrate into chromatin | Retrovirology BioMed Central Research Open Access Intracytoplasmic maturation of the human immunodeficiency virus type 1 reverse transcription complexes determines their capacity to integrate into chromatin Sergey Iordanskiy1 2 Reem Berro3 Maria Altieri1 Fatah Kashanchi3 and Michael Bukrinsky 1 3 Address Department of Microbiology Immunology and Tropical Medicine The George Washington University 2300 I St. . Washington DC 20037 USA 2Department of Molecular Virology The . Ivanovsky Institute of Virology 16 Gamaleya St. Moscow 123098 Russia and 3Department of Biochemistry and Molecular Biology The George Washington University 2300 I St. . Washington DC 20037 USA Email Sergey Iordanskiy- mtmsni@ Reem Berro - rberro@ Maria Altieri - mkostova@ Fatah Kashanchi - bcmfxk@ Michael Bukrinsky - mtmmib@ Corresponding author Published 12 January 2006 Received 10 October 2005 Accepted 12 January 2006 Retrovirology 2006 3 4 doi 86 1742-4690-3-4 This article is available from http content 3 1 4 2006 Iordanskiy et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The early events of the HIV-1 life cycle include entry of the viral core into target cell assembly of the reverse transcription complex RTCs performing reverse transcription its transformation into integration-competent complexes called pre-integration complexes PICs trafficking of complexes into the nucleus and finally integration of the viral DNA into chromatin. Molecular details and temporal organization of these processes remain among the least investigated and most controversial problems in the biology of HIV. Results To quantitatively evaluate maturation and nuclear .

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