tailieunhanh - Báo cáo y học: " Anti-viral RNA silencing: do we look like plants ?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Anti-viral RNA silencing: do we look like plants | Retrovirology BioMed Central Review Anti-viral RNA silencing do we look like plants Anne Saumet and Charles-Henri Lecellier Open Access Address CNRS UPR2357 Institut de Biologie Moléculaire des Plantes 12 rue du General Zimmer 67084 STRASBOURG Cedex France Email Anne Saumet- Charles-Henri Lecellier - Corresponding author Published 12 January 2006 Received 17 December 2005 Accepted 12 January 2006 Retrovirology 2006 3 3 doi 1742-4690-3-3 This article is available from http content 3 1 3 2006 Saumet and Lecellier licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The anti-viral function of RNA silencing was first discovered in plants as a natural manifestation of the artificial co-suppression which refers to the extinction of endogenous gene induced by homologous transgene. Because silencing components are conserved among most if not all eukaryotes the question rapidly arose as to determine whether this process fulfils anti-viral functions in animals such as insects and mammals. It appears that whereas the anti-viral process seems to be similarly conserved from plants to insects even in worms RNA silencing does influence the replication of mammalian viruses but in a particular mode micro mi RNAs endogenous small RNAs naturally implicated in translational control rather than virus-derived small interfering si RNAs like in other organisms are involved. In fact these recent studies even suggest that RNA silencing may be beneficial for viral replication. Accordingly several large DNA mammalian viruses have been shown to encode their own miRNAs. Here we summarize the seminal studies that have implicated RNA silencing in viral .