tailieunhanh - Báo cáo y học: " Targeted infection of HIV-1 Env expressing cells by HIV(CD4/CXCR4) vectors reveals a potential new rationale for HIV-1 mediated down-modulation of CD4"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Targeted infection of HIV-1 Env expressing cells by HIV(CD4/CXCR4) vectors reveals a potential new rationale for HIV-1 mediated down-modulation of CD4 | Retrovirology BioMed Central Research Open Access Targeted infection of HIV-I Env expressing cells by HIV CD4 CXCR4 vectors reveals a potential new rationale for HIV-1 mediated down-modulation of CD4 Zhiping Ye1 2 George G Harmison1 3 Jack A Ragheb4 and Manfred Schubert 1 Address 1Molecular Virology and Neurogenetics Section National Institute of Neurological Disorders and Stroke National Institutes of Health Rm. 4S-18 5625 Fishers Lane Bethesda MD 20892-9403 USA 2Laboratory of Pediatric and Respiratory Viral Diseases Center for Biologics Evaluation and Research Food and Drug Administration Bldg. 29A 8800 Rockville Pike Bethesda MD 20892 USA 3Neurogenetics Branch National Institute of Neurological Disorders and Stroke National Institutes of Health Bldg. 35 Rm. 2A1012 35 Convent Drive Bethesda MD 20892-3705 USA and 4Clinical and Molecular Immunology Section National Eye Institute National Institutes of Health Bldg. 10 Rm. 10N113A 10 Center Drive Bethesda MD 20892-1857 USA Email Zhiping Ye - yez@ George G Harmison - HarmisoG@ Jack A Ragheb - jr50b@ Manfred Schubert - schuberm@ Corresponding author Published 21 December 2005 Received 16 November 2005 Retrovirology 2005 2 80 doi 1742-4690-2-80 Accepted 21 December 2005 This article is available from http content 2 1 80 2005 Ye et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Efficient targeted gene transfer and cell type specific transgene expression are important for the safe and effective expression of transgenes in vivo. Enveloped viral vectors allow insertion of exogenous membrane proteins into their envelopes which could potentially aid in the targeted transduction of .

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