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Each year, million patients are newly diagnosed with active TB and million patients die of TB. The rapid spread of the human immunodeficiency virus has fueled the TB epidemic, especially in sub-Saharan Africa, where 28% of TB patients are HIV positive (WHO 2007). The current first-line treatment for TB is a multidrug regimen consisting of rifampin, isoniazid, pyrazinamide, and ethambutol (RIZE). Several major problems are associated with the currently available TB treatment. There is an increasing incidence of multidrug-resistant (MDR; resistance to at least rifampin and isoniazid) and extensively drug-resistant (XDR; MDR resistance plus resistance. | MENINGITIS Edited by George Wireko-Brobby Meningitis Edited by George Wireko-Brobby Published by InTech Janeza Trdine 9 51000 Rijeka Croatia Copyright 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution license which allows users to download copy and build upon published articles even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech authors have the right to republish it in whole or part in any publication of which they are the author and to make other personal use of the work. Any republication referencing or personal use of the work must explicitly identify the original source. As for readers this license allows users to download copy and build upon published chapters even for commercial purposes as long as the author and publisher are properly credited which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials instructions methods or ideas contained in the book. Publishing Process Manager Tajana Jevtic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published March 2012 Printed in Croatia A free online edition of this book is available at Additional hard copies can be obtained from orders@ Meningitis Edited by George Wireko-Brobby p. cm. ISBN 978-953-51-0383-7 INTECH open science I open minds free online editions of InTech Books and Journals can be found at .

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