tailieunhanh - Báo cáo y học: " Human T-cell leukemia virus type 2 Tax protein induces interleukin 2-independent growth in a T-cell line"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Human T-cell leukemia virus type 2 Tax protein induces interleukin 2-independent growth in a T-cell line. | Retrovirology BioMed Central Short report Open Access Human T-cell leukemia virus type 2 Tax protein induces interleukin 2-independent growth in a T-cell line Rie Kondo11 2 Masaya Higuchi11 Masahiko Takahashi1 Masayasu Oie1 Yuetsu Tanaka3 Fumitake Gejyo2 and Masahiro Fujii 1 Address Division of Virology Niigata University Graduate School of Medical and Dental Sciences 1-757 Asahimachi-Dori Niigata 951-8510 Japan 2Division of Clinical Nephrology and Rheumatology Niigata University Graduate School of Medical and Dental Sciences 1-757 Asahimachi-Dori Niigata 951-8510 Japan and 3Department of Immunology Graduate School and Faculty of Medicine University of the Ryukyus Uehara 207 Nishihara-cho Nakagami-gun Okinawa 903-0215 Japan Email Rie Kondo - rierie-j@ Masaya Higuchi - mhiguchi@ Masahiko Takahashi - masahiko@ Masayasu Oie - moie@ Yuetsu Tanaka - yuetsu@ Fumitake Gejyo - gejyo@ Masahiro Fujii - fujiimas@ Corresponding author tEqual contributors Published 02 December 2006 Received 18 August 2006 Accepted 02 December 2006 Retrovirology 2006 3 88 doi l 742-4690-3-88 This article is available from http content 3 1 88 2006 Kondo et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background While human T-cell leukemia virus type 1 HTLV-1 is a causative agent of adult T-cell leukemia HTLV type 2 HTLV-2 is not associated with this malignancy. Accumulating evidence suggests that Tax a transforming protein of HTLV-1 or HTLV-2 plays a crucial role in the distinctive pathogenesis of these two infections. We herein examined whether Tax2 by itself has a growth promoting activity