tailieunhanh - Báo cáo y học: " Characterization of two candidate genes, NCoA3 and IRF8, potentially involved in the control of HIV-1 latency"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:Characterization of two candidate genes, NCoA3 and IRF8, potentially involved in the control of HIV-1 latency | BioMed Central Retrovirology Research Open Access Characterization of two candidate genes NCoA3 and IRF8 potentially involved in the control of HIV-1 latency Sandie Munier1 Delphine Delcroix-Genête1 Laetitia Carthagéna1 Audrey Gumez1 and Uriel Hazan 1 2 Address 1Département des Maladies Infectieuses Institut Cochin INSERM U567 CNRS UMR-S 8104 Université Paris 5-René Descartes 22 rue Méchain 75014 Paris France and 2UFR de Biochimie Université Paris 7-Denis Diderot 2 Place Jussieu 75251 Paris France Email Sandie Munier - munier@ Delphine Delcroix-Genête - delcroix@ Laetitia Carthagéna - carthagena@ Audrey Gumez - gumez@ Uriel Hazan - hazan@ Corresponding author Published 23 November 2005 Received 28 July 2005 Accepted 23 November 2005 Retrovirology 2005 2 73 doi 1742-4690-2-73 This article is available from http content 2 1 73 2005 Munier et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The persistence of latent HIV-I reservoirs is the principal barrier preventing the eradication of HIV-1 infection in patients by current antiretroviral therapy. It is thus crucial to understand the molecular mechanisms involved in the establishment maintenance and reactivation of HIV-1 latency. Since chromatin remodeling has been implicated in the transcriptional reactivation of the HIV-1 promoter we assessed the role of the histone deacetylase inhibitor sodium butyrate NaB on two HIV-1 latently infected cell lines U1 and ACH-2 gene expression. Results Analysis of microarrays data led us to select two candidate genes NCoA3 Nuclear Receptor Coactivator 3 a nuclear receptor coactivator and IRF8 Interferon .

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