tailieunhanh - Báo cáo y học: " Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1. | Retrovirology BioMed Central Research Dendritic cell-mediated HIV-1 transmission to T cells of LAD-1 patients is impaired due to the defect in LFA-1 Fedde Groot1 2 4 Taco W Kuijpers3 Ben Berkhout1 and Esther C de Jong 2 Open Access Address Department of Human Retrovirology Academic Medical Centre University of Amsterdam Amsterdam The Netherlands 2Department of Cell Biology and Histology Academic Medical Centre University of Amsterdam Amsterdam The Netherlands 3Division of Pediatric Hematology Immunology and Infectious Diseases Emma Children s Hospital Academic Medical Centre University of Amsterdam Amsterdam The Netherlands and 4Present address The Sir William Dunn School of Pathology University of Oxford Oxford United Kingdom Email Fedde Groot - info@ Taco W Kuijpers - Ben Berkhout - Esther C de Jong - Corresponding author Published 01 November 2006 Received 04 September 2006 Accepted 01 November 2006 Retrovirology 2006 3 75 doi l 742-4690-3-75 This article is available from http content 3 1 75 2006 Groot et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Dendritic cells DC have been proposed to mediate sexual HIV-1 transmission by capturing the virus in the mucosa and subsequently presenting it to CD4 T cells. We have demonstrated before that DC subsets expressing higher levels of intercellular adhesion molecule-1 ICAM-1 are better HIV-1 transmitters. ICAM-1 binds leukocyte function-associated molecule-l LFA-l on T cells an integrin responsible for adhesion and signaling at the immunological synapse. To .