tailieunhanh - Báo cáo y học: " Host-virus interaction: a new role for microRNAs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Host-virus interaction: a new role for microRNAs. | Retrovirology BioMed Central Review Host-virus interaction a new role for microRNAs Vinod Scaria Manoj Hariharan Souvik Maiti Beena Pillai and Samir K Brahmachari Open Access Address GN Ramachandran Knowledge Center for Genome Informatics Institute of Genomics and Integrative Biology CSIR Mall Road Delhi 110 007 India Email Vinod Scaria - vinods@ Manoj Hariharan - manoj@ Souvik Maiti - souvik@ Beena Pillai - beenapillai@ Samir K Brahmachari - skb@ Corresponding author Published II October 2006 Received 30 August 2006 Accepted 1 1 October 2006 Retrovirology 2006 3 68 doi 1742-4690-3-68 This article is available from http content 3 1 68 2006 Scaria et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract MicroRNAs miRNAs are a new class of 18-23 nucleotide long non-coding RNAs that play critical roles in a wide spectrum of biological processes. Recent reports also throw light into the role of microRNAs as critical effectors in the intricate host-pathogen interaction networks. Evidence suggests that both virus and hosts encode microRNAs. The exclusive dependence of viruses on the host cellular machinery for their propagation and survival also make them highly susceptible to the vagaries of the cellular environment like small RNA mediated interference. It also gives the virus an opportunity to fight and or modulate the host to suite its needs. Thus the range of interactions possible through miRNA-mRNA cross-talk at the host-pathogen interface is large. These interactions can be further fine-tuned in the host by changes in gene expression mutations and polymorphisms. In the pathogen the high rate of mutations adds to the complexity of the