tailieunhanh - Báo cáo y học: " Natural history of the ERVWE1 endogenous retroviral locus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:Natural history of the ERVWE1 endogenous retroviral locus | Retrovirology BioMed Central Research Open Access Natural history of the ERVWEI endogenous retroviral locus Bertrand Bonnaud1 Jean Beliaeff1 Olivier Bouton1 Guy Oriol1 Laurent Duret2 and Francois Mallet 1 Address 1UMR 2714 CNRS-bioMérieux IFR128 BioSciences Lyon-Gerland Ecole Normale Supérieure de Lyon 46 allée d Italie 69364 Lyon cedex 07 France and 2Laboratoire de Biométrie et Biologie Evolutive UMR CNRS 5558 Université Claude Bernard - Lyon 1 43 Bd du 11 Novembre 1918 69622 Villeurbanne Cedex France Email Bertrand Bonnaud - Jean Beliaeff- Olivier Bouton - Guy Oriol - Laurent Duret - duret@ Francois Mallet - Corresponding author Published 22 September 2005 Received 21 July 2005 Accepted 22 September 2005 Retrovirology 2005 2 57 doi 1742-4690-2-57 This article is available from http content 2 1 57 2005 Bonnaud et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The human HERV-W multicopy family includes a unique proviral locus termed ERVWE1 whose full-length envelope ORF was preserved through evolution by the action of a selective pressure. The encoded Env protein Syncytin is involved in hominoid placental physiology. Results In order to infer the natural history of this domestication process a comparative genomic analysis of the human syntenic regions in eutherians was performed. In primates this region was progressively colonized by LTR-elements leading to two different evolutionary pathways in Cercopithecidae and Hominidae a genetic drift versus a domestication respectively. Conclusion The preservation in .