tailieunhanh - Báo cáo y học: " Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage | Retrovirology BioMed Central Research Open Access Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1 HIV-2 and SIV reveals an efficient SIV HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage Padraig M Strappe 1 David W Hampton2 Douglas Brown1 Begona Cachon-Gonzalez1 Maeve Caldwell2 James W Fawcett2 and Andrew ML Lever 1 Address department of Medicine University of Cambridge Addenbrooke s Hospital Cambridge CB2 2QQ UK and 2Centre for Brain Repair University of Cambridge Addenbrooke s Hospital Cambridge CB2 2QQ UK Email Padraig M Strappe - David W Hampton - dhampton@ Douglas Brown - deb29@ Begona Cachon-Gonzalez - mcb23@ Maeve Caldwell - mac28@ JamesW Fawcett - jf108@ Andrew ML Lever - amll1@ Corresponding author Published 16 September 2005 Received 26 May 2005 Accepted 16 September 2005 Retrovirology 2005 2 55 doi 1742-4690-2-55 This article is available from http content 2 1 55 2005 Strappe et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Lentiviral vectors have shown immense promise as vehicles for gene delivery to non-dividing cells particularly to cells of the central nervous system CNS . Improvements in the biosafety of viral vectors are paramount as lentiviral vectors move into human clinical trials. This study investigates the packaging relationship between gene transfer vector and Gag-Pol expression constructs of HIV-1 HIV-2 and SIV. Cross-packaged vectors expressing GFP were assessed for RNA packaging viral vector titre and their ability to transduce rat .

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN
crossorigin="anonymous">
Đã phát hiện trình chặn quảng cáo AdBlock
Trang web này phụ thuộc vào doanh thu từ số lần hiển thị quảng cáo để tồn tại. Vui lòng tắt trình chặn quảng cáo của bạn hoặc tạm dừng tính năng chặn quảng cáo cho trang web này.