tailieunhanh - Báo cáo y học: " Role of common human TRIM5α variants in HIV-1 disease progression"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Role of common human TRIM5α variants in HIV-1 disease progression. | Retrovirology BioMed Central Open Access Role of common human TRIM5a variants in HIV-I disease progression Valérie Goldschmidt11 Gabriela Bleiber11 Margaret May2 Raquel Martinez1 Millàn Ortiz1 Amalio Telenti 1 and The Swiss HIV Cohort Study Address 1Institute of Microbiology and University Hospital University of Lausanne Switzerland and 2Department of Social Medicine University of Bristol UK Email Valérie Goldschmidt - Gabriela Bleiber - Margaret May - Raquel Martinez - Millàn Ortiz - Amalio Telenti - The Swiss HIV Cohort Study - Corresponding author fEqual contributors Published 22 August 2006 Received 10 April 2006 Accepted 22 August 2006 Retrovirology 2006 3 54 doi l 742-4690-3-54 p g This article is available from http content 3 1 54 2006 Goldschmidt et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background The retroviral restriction factor tripartite motif protein TRIM 5a is characterized by marked amino acid diversity among primates including specific clusters of residues under positive selection. The identification of multiple non-synonymous changes in humans suggests that TRIM5a variants might be relevant to retroviral pathogenesis. Previous studies have shown that such variants are unlikely to modify susceptibility to HIV-1 infection or the course of early infection. However the longterm effect of carrying Trim5a variants on disease progression in individuals infected with HIV-1 has not previously been .