tailieunhanh - Báo cáo y học: " Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission. | Retrovirology BioMed Central Research Differential susceptibility of naive central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission Fedde Groot1 2 Toni MM van Capel2 Joost HN Schuitemaker2 Ben Berkhout1 and Esther C de Jong 2 Open Access Address 1Dept. of Human Retrovirology Academic Medical Centre University of Amsterdam Amsterdam The Netherlands and 2Dept. of Cell Biology and Histology Academic Medical Centre University of Amsterdam Amsterdam The Netherlands Email Fedde Groot - info@ Toni MM van Capel - Joost HN Schuitemaker - Ben Berkhout - Esther C de Jong - Corresponding author Published 17 August 2006 Received 21 June 2006 Accepted 17 August 2006 Retrovirology 2006 3 52 doi l 742-4690-3-52 This article is available from http content 3 1 52 2006 Groot et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Dendritic cells DC have been proposed to facilitate sexual transmission of HIV-1 by capture of the virus in the mucosa and subsequent transmission to CD4 T cells. Several T cell subsets can be identified in humans naive T cells TN that initiate an immune response to new antigens and memory T cells that respond to previously encountered pathogens. The memory T cell pool comprises central memory TCM and effector memory cells TEM which are characterized by distinct homing and effector functions. The TEM cell subset which can be further divided into effector Thl and Th2 cells has been shown to be the prime target for viral replication after HIV-l infection and is abundantly present in mucosal tissues. Results We determined the .